Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome.
Kazutaka SugimotoJoanna YangPaul FischerTsubasa TakizawaInge A MulderTao QinTaylan D ErdoganMohammad A YaseenSava SakadzicDavid Y ChungCenk AyataPublished in: Stroke (2023)
Altogether, these data show that SDs induced noninvasively using optogenetics do not worsen tissue outcomes. Our findings compel a careful reexamination of the notion that SDs are causally linked to infarct expansion.
Keyphrases
- acute ischemic stroke
- high glucose
- diabetic rats
- electronic health record
- acute myocardial infarction
- big data
- drug induced
- heart failure
- oxidative stress
- endothelial cells
- machine learning
- skeletal muscle
- coronary artery disease
- percutaneous coronary intervention
- artificial intelligence
- atrial fibrillation
- acute coronary syndrome
- insulin resistance