Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment.
A LozanoJ MarruecosJ RubióN FarréJ Gómez-MillánR MoreraI PlanasM LanzuelaM G Vázquez-MasedoL CascallarJ GiraltG EscamesVicente ValentíP GrimaR BosserC TarragóR MesíaPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2021)
Treatment with melatonin oral gel showed a consistent trend to lower incidence and shorter SOM duration and shorter duration of UOM. These results warrant further investigation in phase III clinical trial.