Deregulation of desmosomal proteins and extracellular matrix proteases in odontogenic keratocyst.

Marina Gonçalves DinizFilipe Fideles Duarte-AndradeFernanda StussiJéssica Gardone VitórioFlávia Sirotheau Correa PontesRomênia Ramos DominguesAdriana F Paes LemeCarolina Cavaliéri GomesHélder Antônio Rebelo Pontes

Published in: Oral diseases (2020)

Proteomic analysis strengthened the notion that OKC cells have a similar proteomic profile to oral keratinocytes. Contextual investigation of the differentially expressed proteins revealed the deregulation of desmosome proteins and ECM degradation as important alterations in OKC pathobiology.

Keyphrases

extracellular matrix
induced apoptosis
cell cycle arrest
single cell
oxidative stress
cell death
pi k akt