Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants.
Timothy S JohnstonShuk Hang LiMark M PainterReilly K AtkinsonNaomi R DouekDavid B ReegDaniel C DouekE John WherryScott E HensleyPublished in: medRxiv : the preprint server for health sciences (2024)
Variant breakthrough infections boost ancestral cross-reactive antibodies and B cellsFirst and second BA.5 exposures fail to elicit variant-specific antibodies and B cellsXBB infections and monovalent vaccinations elicit XBB.1.5-specific responses in some individualsXBB.1.5-specific responses correlate with low levels of pre-existing humoral immunity.
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