Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas.

Dusten UnruhSnezana MirkovBrian WrayMichael DrummJonathan LamanoYuping D LiQazi F HaiderRodrigo JavierKathleen McCortneyAmanda Muhs SaratsisDenise M ScholtensJann N SarkariaC David JamesCraig Horbinski

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

These data show that TF suppression is a component of IDH1mut glioma behavior, and that it may therefore be an attractive target against IDH1wt gliomas.

Keyphrases

low grade
high grade
wild type
dna methylation
electronic health record
genome wide
gene expression