Feasibility and outcome of reproducible clinical interpretation of high-dimensional molecular data: a comparison of two molecular tumor boards.

Damian T RiekeTill de BortoliPeter HorakMario LampingManuela BenaryIvan JelasGina RüterJohannes BergerMarit ZettwitzNiklas KagelmannAndreas KindFalk FabianDieter BeuleHanno GlimmBenedikt BrorsAlbrecht StenzingerStefan FröhlingUlrich Keilholz

Published in: BMC medicine (2022)

Reproducible clinical interpretation of high-dimensional molecular data is feasible and agreement rates are encouraging, when compared to previous reports. The interpretation of molecular aberrations beyond single nucleotide variants and preclinically validated biomarkers as well as combination therapies were identified as additional difficulties for ongoing harmonization efforts.

Keyphrases

single molecule
electronic health record
copy number
emergency department
big data
adverse drug