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Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.

Anthonius A EzeMatthew K GouldJane C MundayDaniel N A TagoeValters StelmanisAchim SchnauferHarry P de Koning
Published in: PLoS neglected tropical diseases (2016)
Sub-lethal exposure to isometamidium gives rise to viable but highly resistant trypanosomes that, depending on sub-species, are infective to humans and cross-resistant to at least some diamidine drugs. The crucial mutation is in the F1 ATPase γ subunit, which allows loss of kDNA and results in a reduction of the mitochondrial membrane potential.
Keyphrases
  • oxidative stress
  • human health
  • endoplasmic reticulum
  • protein kinase
  • risk assessment
  • climate change
  • drug induced