Direct additive genetics and maternal effect contribute to the risk of Tourette disorder.

Behrang MahjaniLambertus KleiAriela S Buxbaum GriceHenrik LarssonChristina M HultmanSven SandinBernie DevlinJoseph D BuxbaumDorothy E Grice

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

Our results demonstrate genetic maternal effect contributes to the risk of CTD. Failure to account for maternal effect results in an incomplete understanding of the genetic risk architecture of CTD, as the risk for CTD is impacted by maternal effect which is above and beyond the risk from transmitted genetic effect.

Keyphrases

copy number
birth weight
gene expression
physical activity
pregnancy outcomes