Mycobacterium haemophilum infection in canine cerebrospinal fluid.
Kara M De NewJoan R CoatesJim WellehanTamara GullApril ChildressMelanie N AndersonAngela B RoyalPublished in: Veterinary clinical pathology (2023)
A 4-year-old female spayed Australian cattle dog was presented to the Emergency Service at the University of Missouri Veterinary Health Center Small Animal Hospital for generalized pain and lethargy. At presentation, the dog showed severe cervical spinal pain and thoracic limb deficits consistent with a multifocal neuroanatomic localization. Magnetic resonance imaging of the cervical spine revealed T2 and T1 postcontrast intense signal extending from the level of the medulla through C5 most marked in the caudal brainstem and cranial cervical spinal cord. The suspected diagnosis was severe meningoencephalomyelitis and secondary edema. Analysis of cerebrospinal fluid (CSF) collected from the cerebellomedullary cistern revealed a marked mixed pleocytosis with intralesional structures morphologically consistent with Mycobacterium sp. Standard DNA PCR assay performed on the CSF yielded the presence of Mycobacterium haemophilum. To the authors' knowledge, this is the first reported case of CNS mycobacteriosis diagnosed on CSF analysis in a dog.
Keyphrases
- cerebrospinal fluid
- spinal cord
- healthcare
- neuropathic pain
- mycobacterium tuberculosis
- chronic pain
- magnetic resonance imaging
- public health
- mental health
- pain management
- spinal cord injury
- early onset
- single cell
- emergency department
- traumatic brain injury
- pulmonary embolism
- circulating tumor
- health information
- single molecule
- computed tomography
- high resolution
- cell free
- high throughput
- drug induced
- acute care
- climate change
- mass spectrometry
- risk assessment
- diffusion weighted imaging
- nucleic acid
- real time pcr
- postoperative pain