Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells.
Hyung Sik KimJin Woo LeeHari JangThi Phuong Linh LeJun Gu KimMoon Soon LeeJin Tae HongMi Kyeong LeeBang Yeon HwangPublished in: Archives of pharmacal research (2017)
A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC50 values of 18.7-49.4 μM.
Keyphrases
- nitric oxide
- induced apoptosis
- magnetic resonance
- cell cycle arrest
- high resolution mass spectrometry
- oxidative stress
- liquid chromatography
- nitric oxide synthase
- hydrogen peroxide
- cell death
- magnetic resonance imaging
- inflammatory response
- signaling pathway
- big data
- electronic health record
- molecular dynamics simulations
- ms ms
- pi k akt