Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation.

Laura CampderrósRicardo MoureMontserrat CairóAleix Gavaldà-NavarroTania Quesada-LópezRubén CereijoMarta GiraltJoan VillarroyaFrancesc Villarroya

Published in: Obesity (Silver Spring, Md.) (2019)

GDF15 is a brown adipokine released by brown and beige cells in response to thermogenic activity. GDF15 released by BAT targets macrophages and may mediate downregulation of local inflammatory pathways.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
oxidative stress
adipose tissue
cell proliferation
endoplasmic reticulum stress
cell death
pi k akt
insulin resistance