Assessment of the Effect of Metabolic Syndrome on the Autophagy Marker LC3 in Psoriasis Vulgaris Patients: A Cross-Sectional Study.
Essam A NadaEman M S MuhammadSheren F M AhmedAsmaa M S TamamAmr AbdelhamedPublished in: Clinical, cosmetic and investigational dermatology (2020)
A potential link between psoriasis vulgaris and autophagy as assessed by LC3 could be present. LC3 was down-regulated in psoriasis lesions than in normal skin. However, its expression did not change with PASI or MetS. An autophagy enhancer might be used as a possible therapeutic target in psoriasis vulgaris patients.
Keyphrases
- end stage renal disease
- metabolic syndrome
- cell death
- newly diagnosed
- chronic kidney disease
- ejection fraction
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- simultaneous determination
- prognostic factors
- peritoneal dialysis
- transcription factor
- type diabetes
- cardiovascular disease
- insulin resistance
- adipose tissue
- skeletal muscle
- risk factors
- patient reported outcomes
- human health