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Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus.

Huai-Chia ChuangWei-Ting HungYi Ming ChenPu-Ming HsuJeng-Hsien YenJoung-Liang LanTse-Hua Tan
Published in: Annals of the rheumatic diseases (2021)
Multiple GLK germline and somatic variants cause GLK induction by increasing mRNA or protein stability in patients with SLE.
Keyphrases
  • copy number
  • systemic lupus erythematosus
  • disease activity
  • dna repair
  • genome wide
  • dna methylation
  • binding protein
  • single cell
  • rheumatoid arthritis
  • amino acid
  • gene expression
  • dna damage
  • high density
  • small molecule