N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA.

Xiao ZhengQi WangYou ZhouDachuan ZhangYiting GengWenwei HuChangping WuYufang ShiJing Ting Jiang

Published in: Cancer communications (London, England) (2022)

Our study revealed that NAT10 plays a critical role in colon cancer development by affecting FSP1 mRNA stability and ferroptosis, suggesting that NAT10 could be a novel prognostic and therapeutic target in colon cancer.

Keyphrases

cell death
binding protein
signaling pathway
single cell
protein protein
small molecule