Restrictive resuscitation in patients with sepsis and mortality: A systematic review and meta-analysis with trial sequential analysis.

Paul M ReynoldsSylvia StefanosRobert MacLaren

Published in: Pharmacotherapy (2023)

This study demonstrated that a restrictive resuscitation strategy in sepsis resulted in no difference in mortality but may reduce ventilator days. Larger randomized trials are required to determine the optimal management of fluids in patients with sepsis.

Keyphrases

septic shock
acute kidney injury
intensive care unit
cardiac arrest
cardiovascular events
cardiopulmonary resuscitation
risk factors
acute respiratory distress syndrome
mechanical ventilation
phase iii
phase ii
coronary artery disease
open label
extracorporeal membrane oxygenation