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The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice.

Troy L MerryAnna E S BrooksStewart W MassonShannon E AdamsJagdish K JaiswalStephen M F JamiesonPeter R Shepherd
Published in: International journal of obesity (2005) (2019)
Our results indicate that macrophage infiltration of adipose tissue induced by a high-fat diet may not be the trigger for impairments in whole body glucose homeostasis, and that anti-CSF1 therapies are not likely to be useful as treatments for insulin resistance.
Keyphrases
  • adipose tissue
  • high fat diet
  • insulin resistance
  • high fat diet induced
  • blood glucose
  • polycystic ovary syndrome
  • skeletal muscle
  • metabolic syndrome
  • type diabetes
  • glycemic control
  • binding protein