Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation.

Seung Sik YooDong Won LeeHyeon Joo HamIn Jun YeoJu Young ChangJaesuk YunDong Ju SonSang-Bae HanJin Tae Hong

Published in: CNS neuroscience & therapeutics (2023)

Depression increases the risk of developing AD and other forms of dementia. Recent evidence indicates that depression symptoms could trigger changes in memory and thinking over time. However, it is recognized that there are no drugs to facilitate a full recovery for both AD and depression. However, our results suggest that AD and depression could be associated, and DVL could be a significant target for the association between AD and depression.

Keyphrases

depressive symptoms
sleep quality
physical activity
metabolic syndrome
bipolar disorder
adipose tissue
early onset
cognitive impairment
stress induced
insulin resistance