Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells.

Christine RossmannChristoph NussholdMargret PaarGerhard LedinskiErwin TafeitMartin KoestenbergerEva Maria BernhartWolfgang SattlerGerhard CvirnSeth Hallström

Published in: PloS one (2018)

EP has the potential for an anti-atherosclerotic drug by attenuating both, the oxidation of LDL and the cytotoxic effect of (already formed) oxLDL in EA.hy926 cells. Chronic administration of EP might be beneficial to impede the development of atherosclerotic lesions.

Keyphrases

induced apoptosis
cell cycle arrest
hydrogen peroxide
endoplasmic reticulum stress
signaling pathway
emergency department
nitric oxide
cell proliferation
risk assessment
adverse drug