Boron-cluster-based porous BCN material modified electrode for electrochemical determination of morphine in serum.

Porous highly boron-doped BCN (p-BCN) was produced by using a boron cluster salt (closo-[B 12 H 12 ] 2- ) as the boron-based precursor and SiO 2 as a hard template. The synthesized p-BCN was used in an electrochemical sensor for the ultrasensitive and highly selective detection of morphine (MOP). The optimal conditions for MOP detection were determined by optimizing the experimental conditions. Under these optimal conditions, the p-BCN-based sensor exhibited excellent MOP detection performance (working potential of 0.2 V). Specifically, it showed a detection range of 0.05 to 200 μM and a detection limit of 17.8 nM. Notably, the p-BCN-based electrochemical sensor was successfully applied to the determination of MOP in human blood, and the results showed satisfactory recovery and accuracy. Therefore, this sensor can be used as an effective platform for the detection of MOP in human blood samples.