Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells.

Léonard HéraultMathilde PoplineauAdrien MazuelNadine PlatetÉlisabeth RemyEstelle Duprez

Published in: BMC biology (2021)

Our results establish a new reference map of HSC differentiation in young and aged mice and reveal a potential mechanism that delays the differentiation of aged HSCs and could promote the emergence of age-related hematologic diseases.

Keyphrases

single cell
rna seq
cell cycle
cell proliferation
high throughput
induced apoptosis
cell cycle arrest
metabolic syndrome
risk assessment
signaling pathway
oxidative stress
climate change