Associations Between Thinner Retinal Neuronal Layers and Suboptimal Brain Structural Integrity in a Middle-Aged Cohort.
Ashleigh Barrett-YoungWickliffe C AbrahamCarol Y CheungJesse GaleSean HoganDavid IrelandRoss KeenanAnnchen R KnodtTracy R MelzerTerrie E MoffittSandhya RamrakhaYih Chung ThamGraham A WilsonTien Yin WongAhmad R HaririRichie PoultonPublished in: Eye and brain (2023)
These findings provide evidence that the retinal neuronal layers reflect differences in midlife structural brain integrity consistent with increased risk for later AD, supporting the proposition that the retina may be an early biomarker of brain health.