Ruthenium-Catalyzed Selective C-C Coupling of Allylic Alcohols with Free Indoles: Influence of the Metal Catalyst.

Ying-Qi XiaChao LiMan LiuLin Dong

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)

Versatile reactive activities of allyl alcohols with free indoles in C-H functionalization reactions were investigated. Direct alkylation or cascade cyclization reactions could be selectively controlled based on the catalyst system: Ru(PPh3 )3 Cl2 provided C3-substituted β-ketone indoles whereas [Ru(p-cymene)Cl2 ]2 yielded cyclized indoles.

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