PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma.
Henry G SmithDavid MansfieldVictoria RoulstoneJoan N KyulaMartin McLaughlinRadhika R PatelKatharina F BergerhoffJames T E PagetMagnus T DillonAadil KhanAlan MelcherKhin ThwayKevin J HarringtonAndrew J HayesPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Viral ILP augments the response to PD-1 blockade, transforming this locoregional therapy into a potentially effective systemic treatment for sarcoma and warrants translational evaluation.