Narciclasine induces autophagy-dependent apoptosis in triple-negative breast cancer cells by regulating the AMPK-ULK1 axis.

Chuan CaoWei HuangNan ZhangFengbo WuTing XuXiaoli PanCheng PengBo Han

Published in: Cell proliferation (2018)

Our findings suggest that narciclasine regulates the AMPK-ULK1 signalling axis to promote autophagy-dependent apoptosis, demonstrating therapeutic potential against TNBC.

Keyphrases

endoplasmic reticulum stress
cell death
oxidative stress
cell cycle arrest
breast cancer cells
skeletal muscle
signaling pathway
protein kinase
pi k akt
cell proliferation