The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia.

Kristin MagesFelix GrassmannHerbert JägleRainer RupprechtBernhard H F WeberStefanie M HauckAntje Grosche

Published in: Journal of neuroinflammation (2019)

In sum, our data imply that beneficial effects of XBD173 treatment on the postischemic survival of inner retinal neurons were primarily mediated by stabilizing neurosupportive functions of glial cells.

Keyphrases

optical coherence tomography
diabetic retinopathy
optic nerve
spinal cord
induced apoptosis
neuropathic pain
cell cycle arrest
electronic health record
cell death
big data
combination therapy
computed tomography
smoking cessation