The Role of Adenosine Receptor A2A in the Regulation of Macrophage Exosomes and Vascular Endothelial Cells During Bone Healing.

Dong WangJingyi WangJunlin Zhou Xi Zheng

Published in: Journal of inflammation research (2021)

The activation of ADA2AR was essential for angiogenesis and the secretion of exosomes by macrophages during bone healing; moreover, the inactivation of the ADA2AR led to poor angiogenesis and bone nonunion.

Keyphrases

endothelial cells
bone mineral density
mesenchymal stem cells
vascular endothelial growth factor
soft tissue
stem cells
bone loss
bone regeneration
high glucose
postmenopausal women
adipose tissue
wound healing
body composition
protein kinase