Allergen skin test reactivity and asthma are inversely associated with ratios of IgG4/IgE and total IgE/allergen-specific IgE in Ugandan communities.
Gyaviira NkurunungiJacent NassuunaHarriet MpairweJoyce KabagenyiMargaret NampijjaRichard E SanyaEmily L WebbAlison M ElliottPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
Our immuno-epidemiological data support the hypothesis that the IgG4-IgE balance and the total IgE-allergen-specific IgE balance are more important than absolute total, helminth- or allergen-specific antibody levels in inhibition of allergies in the tropics.