Unveiling blood pressure-associated genes in aortic cells through integrative analysis of GWAS and RNA modification-associated variants.
Huan ZhangYuxi ChenPeng XuDan LiuNaqiong WuLaiyuan WangXing-Bo MoPublished in: Chronic diseases and translational medicine (2024)
The present study identified RNAm-SNPs in BP loci and elucidated the associations between the RNAm-SNPs, gene expression, and BP. The identified BP-associated genes in aortic cells were associated with AD.
Keyphrases
- genome wide
- induced apoptosis
- gene expression
- blood pressure
- dna methylation
- cell cycle arrest
- aortic valve
- copy number
- left ventricular
- pulmonary artery
- endoplasmic reticulum stress
- type diabetes
- heart failure
- metabolic syndrome
- oxidative stress
- genome wide association
- coronary artery
- atrial fibrillation
- insulin resistance
- pi k akt