Identifying People at High Risk for Severe Aortic Stenosis: Aortic Valve Calcium Versus Lipoprotein(a) and Low-Density Lipoprotein Cholesterol.

Natalie Marrero Kunal Jha Alexander C RazaviEllen BoakyeKhalil AnchoucheOmar Dzaye Matthew J Budoff Michael Y Tsai Sanjiv J Shah Jerome I Rotter Xiuqing Guo Jie Yao Roger Scott Blumenthal George Thanassoulis Wendy S Post Michael J BlahaSeamus P Whelton

Published in: Circulation. Cardiovascular imaging (2024)

AVC better identifies people at high risk for severe AS compared with Lp(a) or LDL-C, and people with AVC=0 have a very low long-term rate of severe AS regardless of Lp(a) or LDL-C level. These results suggest AVC should be the preferred prognostic risk marker to identify patients at high risk for severe AS, which may help inform participant selection for future trials testing novel strategies to prevent severe AS.

Keyphrases

aortic valve
aortic stenosis
ejection fraction
transcatheter aortic valve replacement
early onset
aortic valve replacement
transcatheter aortic valve implantation
drug induced
heart failure
coronary artery disease
patient reported outcomes