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Enantioselective Silylation of Aliphatic C-H Bonds for the Synthesis of Silicon-Stereogenic Dihydrobenzosiloles.

Bo YangWu YangYonghong GuoLijun YouChuan He
Published in: Angewandte Chemie (International ed. in English) (2020)
A rhodium(I)-catalyzed enantioselective silylation of aliphatic C-H bonds for the synthesis of silicon-stereogenic dihydrobenzosiloles is demonstrated. This reaction involves a highly enantioselective intramolecular C(sp3 )-H silylation of dihydrosilanes, followed by a stereospecific intermolecular alkene hydrosilylation leading to the asymmetrically tetrasubstituted silanes. A wide range of dihydrosilanes and alkenes displaying various functional groups are compatible with this process, giving access to a variety of highly functionalized silicon-stereogenic dihydrobenzosiloles in good to excellent yields and enantioselectivities.
Keyphrases
  • energy transfer
  • quantum dots
  • room temperature
  • mass spectrometry
  • transition metal
  • tandem mass spectrometry