Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2-Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma.

Debora Lucia Seguro DanilovicEvandro Sobroza de MelloEliana Salgado Turri FrazzatoAlda WakamatsuAlexander Augusto de Lima JorgeAna Oliveira HoffSuemi Marui

Published in: Head & neck (2018)

We identified mutations in KEAP1 associated with Nrf2 overexpression in PTC. Mutations favored disruption of inhibitory interaction Nrf2-Keap1 to enable increased antioxidant Nrf2 activity, possibly with prognostic consequences.

Keyphrases

oxidative stress
protein protein
transcription factor
lymph node
squamous cell carcinoma