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HIV virologic response, patterns of drug resistance mutations and correlates among adolescents and young adults: A cross-sectional study in Tanzania.

Joan RugemalilaDoreen KamoriPeter KunambiMucho MizindukoAmon SabasabaSalim MasoudFrank MsafiriSabina MugusiRita MutagondaLinda MlundeDavis Elias AmaniErick MboyaMacdonald MahitiGeorge RuhagoJeremiah MushiVeryeh SambuGeorge MgomellaBoniface JulluWerner MaokolaProsper NjauBeatrice MutayobaGodfrey BarabonaTakamasa UenoAndrea Barnabas PembeTumaini NaguBruno SunguyaSaid Aboud
Published in: PloS one (2023)
VS amongst AYA is lower than the third UNAIDs target. Additionally, a high prevalence of ADR and high levels of circulating clinically relevant DRMs may compromise the long-term VS in AYA. Furthermore, the first VL result of ≥1000copies/ml after ART initiation is a significant risk factor for developing DRMs. Thus, strict VL monitoring for early identification of treatment failure and genotypic testing during any ART switch is recommended to improve treatment outcomes for AYA.
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