Kaempferol-3-O-sophoroside contributes to modulation of depressive-like behavior in C57BL/6J mice by activating AMPK.

Rong WangXiaolong HuShumeng LiuJingjin WangFei XiongXiaoqi ZhangWencai YeHao Wang

Published in: British journal of pharmacology (2023)

PCS-1 binds to AMPK to promote BDNF production and autophagy enhancement, ultimately achieving antidepressant effects. This study provides support for the clinical application of saffron petals and provides further evidence for AMPK as a potential target for antidepression.

Keyphrases

skeletal muscle
signaling pathway
protein kinase
major depressive disorder
cell death
bipolar disorder
oxidative stress
endoplasmic reticulum stress
risk assessment
climate change