Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via NLRP3 inflammasome in mouse models of obesity.
Ji H HanHanho ShinJun G RhoJung-Eun KimDong H SonJuhwan YoonYong J LeeJung-Hyuck ParkByung J SongChang-Sik ChoiSeul G YoonIl Y KimEun K LeeJe K SeongKi Woo KimWook KimPublished in: Diabetes, obesity & metabolism (2018)
These results suggest that peripheral CB1R blockade improves obesity-induced insulin resistance by suppressing adipose tissue inflammation via the NLRP3 inflammasome.
Keyphrases
- nlrp inflammasome
- insulin resistance
- adipose tissue
- high fat diet
- high fat diet induced
- oxidative stress
- metabolic syndrome
- polycystic ovary syndrome
- skeletal muscle
- diabetic rats
- mouse model
- type diabetes
- high glucose
- chemotherapy induced
- weight loss
- glycemic control
- radiation induced
- physical activity
- drug induced
- endothelial cells
- radiation therapy
- body mass index
- binding protein