Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity.
Anirban Goutam MukherjeeUddesh Ramesh WanjariValsala Gopalakrishnan AbilashSandra KannampuzhaReshma MuraliArunraj NamachivayamGanesan RajaKaviyarasi RenuAbhijit DeyBalachandar VellingiriPrabakaran D SPublished in: Vaccines (2023)
COVID-19 has become a significant public health concern that has catastrophic consequences for society. Some preliminary evidence suggests that the male reproductive system may be an infection target for SARS-CoV-2. SARS-CoV-2 may be transmitted sexually, according to preliminary research. Testicular cells exhibit a high level of the angiotensin-converting enzyme 2 (ACE2) receptor, which enhances the entry of the SARS-CoV-2 into host cells. Some instances of COVID-19 have been documented to exhibit hypogonadism during the acute stage. Furthermore, systemic inflammatory reactions triggered by SARS-CoV-2 infection may cause oxidative stress (OS), which has been shown to have profoundly deleterious consequences on testicular functioning. This work gives a clear picture of how COVID-19 may affect male reproductive systems and calls attention to the many unanswered questions about the mechanisms by which this virus can be linked to men's health and fertility.
Keyphrases
- dna damage
- sars cov
- oxidative stress
- respiratory syndrome coronavirus
- induced apoptosis
- public health
- angiotensin converting enzyme
- coronavirus disease
- angiotensin ii
- healthcare
- cell cycle arrest
- signaling pathway
- liver failure
- working memory
- endoplasmic reticulum stress
- binding protein
- climate change
- germ cell
- mechanical ventilation
- cell proliferation
- aortic dissection
- human health
- young adults
- pi k akt
- middle aged