TRAIL-conjugated silver nanoparticles sensitize glioblastoma cells to TRAIL by regulating CHK1 in the DNA repair pathway.

Ilknur Sur-ErdemKerem MusluNareg PınarbasıMine AltunbekFidan Seker-PolatAhmet Cingöz Serdar Onur AydinMehmet KahramanMustafa CulhaIhsan SolarogluTugba Bagcı-Önder

Published in: Neurological research (2020)

These results suggest that TRAIL sensitivity of TR cells can be enhanced by conjugation of TRAIL with AgNPs, which would be a novel therapeutic approach to sensitize TRAIL resistance.

Keyphrases

silver nanoparticles
dna repair
induced apoptosis
cell cycle arrest
dna damage
dna damage response
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell death
pi k akt