Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance.
Rabi R DattaSimon SchranOana-Diana PersaClaire AguilarMartin ThelenJonas LehmannMaria A Garcia-MarquezKerstin WennholdElla PreugszatPeter ZentisMichael S von Bergwelt-BaildonAlexander QuaasChristiane J BrunsChristine E KurschatCornelia MauchHeike LoeserDirk Ludger StippelHans Anton SchlößerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our study demonstrates the impact of immunosuppression on the TME and supports impaired cancer immunosurveillance as important cause of post-transplant cancer. Modern immunosuppressive protocols and cancer therapies should consider the distinct immune microenvironment of post-transplant malignancies.