Generation of human antibodies targeting human platelet antigen (HPA)-1a.

Janita J OosterhoffFederica LintyRemco VisserThijs de VosSuzanne Hofstede-van EgmondMiranda van de WeerdLeendert PorcelijnMasja de HaasEllen van der SchootGestur Vidarsson

Published in: Transfusion (2024)

This study outlined an effective method for the isolation of HPA-1a-specific B-cells and the generation of monoclonal antibodies. Further characterization of these antibodies holds promise for better understanding the pathogenic nature of alloantibodies in FNAIT.

Keyphrases

endothelial cells
induced pluripotent stem cells
machine learning
drug delivery
big data
deep learning