Renal impairment is prevalent in pediatric NAFLD/MASLD and associated with disease severity.
Marialena MouzakiKatherine P YatesAna Catalina Arce-ClacharCindy BehlingNiviann M BlondetMark H FishbeinFrancisco FloresKathryn Harlow AdamsPaula HertelAjay K JainJean P MollestonJeffrey B SchwimmerMiriam B VosStavra A Xanthakosnull nullPublished in: Journal of pediatric gastroenterology and nutrition (2024)
Renal impairment is prevalent in children with NAFLD/MASLD and hyperfiltration is independently associated with significant liver fibrosis. Almost 1/5 children have evidence of progression in renal dysfunction over 2 years, not associated with change in liver disease severity. Future assessments including additional renal impairment biomarkers are needed.