Detection of IFNγ-Secreting CD4+ and CD8+ Memory T Cells in COVID-19 Convalescents after Stimulation of Peripheral Blood Mononuclear Cells with Live SARS-CoV-2.
Victoria MatyushenkoIrina Isakova-SivakIgor KudryavtsevArina GoshinaAnna ChistyakovaEkaterina StepanovaPolina ProkopenkoIvan SychevLarisa RudenkoPublished in: Viruses (2021)
The stimulation of immune cells with live SARS-CoV-2 revealed a rapid decline in the pool of effector memory CD8+, but not CD4+, T cells after recovery from COVID-19. These data provide additional information on the development and persistence of cellular immune responses after natural infection, and can inform further development of T cell-based SARS-CoV-2 vaccines.