Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma.

Mary K McKennaAda OzcanDaniel BrennerNorihiro WatanabeMaureen LegendreDafydd G ThomasChristopher AshwoodRichard D CummingsChallice BonifantDavid M MarkovitzMalcolm K Brenner

Published in: Journal for immunotherapy of cancer (2023)

T cells expressing H84T CAR target malignant cells and their stroma in PDAC tumor models. The incorporation of glycan-targeting lectins within CARs thus extends their activity to include both malignant cells and their supporting stromal cells, disrupting the TME that otherwise diminishes the activity of cellular therapies against solid tumors.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation
cancer therapy
cell surface