A three protein signature fails to externally validate as a biomarker to predict surgical outcome in high-grade epithelial ovarian cancer.

Amy HawardenMarcus PriceBryn RussellGodfrey WilsonLaura FarrellyAndrew Embleton-ThirskMahesh ParmarRichard John Edmondson

Published in: PloS one (2023)

Despite showing original promise, when this protein signature is applied to a large external cohort, it is unable to accurately predict surgical outcomes. This could be attributed to overfitting of the original model, or differences in surgical practice between cohorts.

Keyphrases

high grade
protein protein
healthcare
primary care
amino acid
binding protein
big data
machine learning
quality improvement
artificial intelligence