A three protein signature fails to externally validate as a biomarker to predict surgical outcome in high-grade epithelial ovarian cancer.
Amy HawardenMarcus PriceBryn RussellGodfrey WilsonLaura FarrellyAndrew Embleton-ThirskMahesh ParmarRichard John EdmondsonPublished in: PloS one (2023)
Despite showing original promise, when this protein signature is applied to a large external cohort, it is unable to accurately predict surgical outcomes. This could be attributed to overfitting of the original model, or differences in surgical practice between cohorts.