Login / Signup

A three protein signature fails to externally validate as a biomarker to predict surgical outcome in high-grade epithelial ovarian cancer.

Amy HawardenMarcus PriceBryn RussellGodfrey WilsonLaura FarrellyAndrew Embleton-ThirskMahesh ParmarRichard John Edmondson
Published in: PloS one (2023)
Despite showing original promise, when this protein signature is applied to a large external cohort, it is unable to accurately predict surgical outcomes. This could be attributed to overfitting of the original model, or differences in surgical practice between cohorts.
Keyphrases
  • high grade
  • protein protein
  • healthcare
  • primary care
  • amino acid
  • binding protein
  • big data
  • machine learning
  • quality improvement
  • artificial intelligence