Natural history of histologically benign PIRADS 4-5 lesions in multiparametric MRI: Real-life experience in an academic center.
Serdar MadendereMert KilicHatice ZorogluAhmet Furkan SarikayaMert VeznikliBilgen CoskunAyse ArmutluIbrahim KulacBengi GürsesMurat Can KiremitDilek Ertoy BaydarAbdullah Erdem CandaMevlana Derya BalbayMetin VuralYakup KordanTarik EsenPublished in: The Prostate (2024)
Patients should be warned against the relative relaxing effect of a negative biopsy after identification of PIRADS 4-5 index lesion. While PSA decrease was observed in many patients during follow-up, persistent MRI findings were present in nearly a quarter of patients with persistently high PSA. A rebiopsy is warranted in these patients, with significant prostate cancer diagnosed in a quarter of patients with rebiopsy.