Characterisation of T cell receptor repertoires in coeliac disease.

Lik Wee LeeShahin ShafianiBeryl CrossleyRyan O EmersonDavid WilliamsonAnna BuninJustin VargasArnold S HanIan M KaplanPeter H R GreenIlan KirschGovind Bhagat

Published in: Journal of clinical pathology (2022)

Small intestinal TRB and TRG repertoires of patients with CD are more diverse than individuals without CD, likely due to mucosal recruitment and accumulation of T cells because of protracted inflammation. Enrichment of the unique TRG CDR3 AA sequence in the mucosa of patients with CD may suggest disease-associated changes in the TCRγδ IE lymphocyte (IEL) landscape.

Keyphrases

nk cells
oxidative stress
regulatory t cells
peripheral blood
dendritic cells
binding protein