External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients.
Y L WangR GuilhaumouO BlinL VellyAmélie MarsotPublished in: European journal of clinical pharmacology (2020)
While performing external evaluations on some populations may confirm a model's suitability to diverse groups of patients, there is still some variability that cannot be explained nor solved by the procedure. This brings to light the difficulty to develop only one model for ICU patients and the need to develop one specific model to each population of critically ill patients.