Causal Association Between Subtypes of Excessive Daytime Sleepiness and Risk of Cardiovascular Diseases.
Matthew O GoodmanHassan S DashtiJacqueline M LaneDaniel P WindredAngus BurnsSamuel E JonesTamar SoferShaun M PurcellXiaofeng ZhuHanna M OllilaSimon D KyleKai SpiegelhalderYüksel PekerTianyi HuangSean W CainAndrew J K PhillipsRicha SaxenaMartin K RutterSusan RedlineHeming WangPublished in: Journal of the American Heart Association (2023)
Our study suggests the previous evidence linking EDS with increased cardiovascular disease risk may be primarily driven by the effect of its long-sleep subtype on higher risk of MI. Underlying mechanisms remain to be investigated but may involve sleep irregularity and circadian disruption, suggesting a need for novel interventions in this population.