Development, production and characterization of SARS-CoV-2 virus-like particles (Coronaviridae: Orthocoronavirinae: Betacoronavirus: Sarbecovirus ).

O E Latyshev O N Zaykova Olesja Eliseeva T E Savochkina Yana Yu Chernoryzh A V Syroeshkin Gleb V Petrov G K Vorkunova Viktor F Larichev I T Fediakina Stanislav A Cherepushkin V V Tsibezov K A Yuzhakova Nadezhda Kulikova Varvara V Lebedeva D Y Yakunin A A Kozlova M S Baranets Kirill I Yurlov Ekaterina I Lesnova Tatiana Vladimirovna Grebennikova

Published in: Voprosy virusologii (2024)

The production and purification of recombinant VLPs consisting of full-length SARS-CoV-2 proteins with a universal set of surface antigens have been developed and optimized. Self-assembling particles that mimic the coronavirus virion induce a specific immune response against SARS-CoV-2.

Keyphrases

sars cov
respiratory syndrome coronavirus
immune response
dendritic cells
cell free