Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy.
Lydia S H LeeWen Chean LimDaria Galas-FilipowiczKent FungJulia TaylorDominic PatelZulaikha AkbarElena Alvarez MediavillaPatrycja WawrzynieckaDebarati ShomeRogier M ReijmersTrillian GreggLeigh WoodWilliam DayVirginie CerecMathieu FerrariSimon ThomasShaun CordobaShimobi OnuohaNushmia KhokharVijay PeddareddigariMuhammad Al-HajjJim CavetSonja ZweegmanManuel Rodriguez-JustoKwee YougMartin PuleRakesh PopatPublished in: Journal for immunotherapy of cancer (2023)
The APRIL CAR was well tolerated, but the clinical responses observed in AUTO2 were disappointing. Subsequently, when comparing the APRIL CAR to other BCMA CARs, we observed in vitro functional deficiencies due to reduced target binding by cell-expressed ligand.