Decreased sirtuin 4 levels promote cellular proliferation and invasion in papillary thyroid carcinoma.

Hyun-Jin LeeYoung-Sool HahSo Young CheonSeong Jun WonChae Dong YimSomi RyuSeung-Jun LeeJi Hyun SeoJung Je Park

Published in: European thyroid journal (2024)

This study provides novel insight into the potential contribution of SIRT4 to the regulation of the pathological progression of PTC. The data suggest that SIRT4 plays a tumor-suppressive role in PTC by inhibiting growth, survival, and invasive potential. Future research should investigate the molecular mechanisms underlying these effects of SIRT4.

Keyphrases

oxidative stress
ischemia reperfusion injury
lymph node
signaling pathway
human health
lymph node metastasis
electronic health record
current status
squamous cell carcinoma
machine learning
big data
risk assessment
climate change
single molecule
artificial intelligence