Hepatocyte-derived MANF alleviates hepatic ischaemia-reperfusion injury via regulating endoplasmic reticulum stress-induced apoptosis in mice.
Yi YangPeng WangChaoyi ZhangFan HuangGaozong PangChuansheng WeiChangming LvGoma ChhetriTongcui JiangJun LiuYujun ShenYu-Xian ShenPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Collectively, our study unravels a previously unknown relationship among MANF, UPR and hepatic I/R injury.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- signaling pathway
- oxidative stress
- acute myocardial infarction
- cerebral ischemia
- heart failure
- mouse model
- acute ischemic stroke
- metabolic syndrome
- skeletal muscle
- atrial fibrillation
- insulin resistance
- acute coronary syndrome
- type diabetes
- percutaneous coronary intervention